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KMID : 0984720040360030185
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Infection and Chemotherapy
2004 Volume.36 No. 3 p.185 ~ p.188
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A Case of Kikuchi´s disease accompanied by Hemophagocytic Lymphohistiocytosis
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Oh Jun-Hyok
Park Ju-Hyun
Hwang Sang-Youn
Lee Sun-Hee
Kim Sung-Il
Kim Jee-Yeon
Lee Chang-Hoon
Chung Joo-Seop
Lee Eun-Yup
Cho Goon-Jae
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Abstract
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Kikuchi´s disease usually occurs in young women and is characterized by localized lymphadenitis (mostly cervical) usually associated with fever. It is considered a self-limited disease and most patients recover spontaneously within a few weeks to 6 months without any serious sequelae. However, patients with Kikuchi´s disease require a systemic survey and regular follow-up for several years because it may be associated with other diseases such as systemic lupus erythematosus. To our knowledge, there are very few reports of Kikuchi´s disease accompanied by hemophagocytic lymphohistiocytosis. Biopsy of a right cervical lymph node in a 35-year-old female who presented with fever and masses in the right cervical region showed necrotizing lymphadenitis and a diagnosis of Kikuchi´s disease was reached. She was started on methylprednisolone pulse therapy (500 mg for 3 days) but developed generalized rash and fever. Laboratory data showed pancytopenia, elevation of serum transaminase and ferritin levels. Bone marrow and liver biopsy showed proliferation of histiocytes and Kupffer´s cells engulfing lymphocytes, platelets and red blood cells, respectively. We report a case of Kikuchi´s disease accompanied by hemophagocytic lymphohistiocytosis
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KEYWORD
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Kikuchi´s disease, Hemophagocytic lymphohistiocytosis
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